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KMID : 0363320000210030399
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 3 p.399 ~ p.407
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Underlying mechanism of antioxidant action of Haejohwan in thyroxine-induced hyperthyroid rats
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Park Jong-Hyuk
Yoon Cheol-Ho
Seo Un-Kyo
Jung Ji-Chun
Kang Jeong-Jun
Seo Jong-Eun
Shin Uk-Seob
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Abstract
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This study was carried out to examine if Haejohwan (HJ) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats.
Triiodothyronine (Τ₃) , thyroxine(T₄) , lipid peroxidation, xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in HJ extract’s pre-applied group. Glutathione level, activities of glutathione peroxidase, glutathione Stransferase and glutathione reductase were decreased in thyroxine treated group. But, they were increased in HJ extract’s pre-applied group.
These results suggest that in thyroxine-induced hyperthyroid rats HJhas an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities, and prevents lipid peroxidation.
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KEYWORD
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Haejohwan, hyperthyroidism, lipid peroxidation, oxygen free radical scavenging enzyme, xanthine oxidase, glutathione
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